发明名称 |
Gene therapy methods using bone marrow-derived cells |
摘要 |
A method for expressing a recombinant protein from bone marrow-derived cells comprises the steps of treating the bone marrow-derived cells in vitro with a TGFbeta1 protein, which selects a population of the cells for further treatment. The selected cells can then be expanded, after which a gene encoding a therapeutic protein can be inserted into the expanded cells and thereafter express the therapeutic protein. The transduced cells can then be introduced into a mammal to produce a therapeutic result.
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申请公布号 |
US2002141982(A1) |
申请公布日期 |
2002.10.03 |
申请号 |
US20020076981 |
申请日期 |
2002.02.15 |
申请人 |
UNIVERSITY OF SOUTHERN CALIFORNIA, A CALIFORNIA CORPORATION |
发明人 |
GORDON ERLINDA MARIA;HALL FREDERICK L.;ANDERSON W. FRENCH |
分类号 |
C12N15/09;A61K31/711;A61K35/12;A61K35/28;A61K38/43;A61K48/00;C12N5/02;C12N5/0775;C12N5/10;C12P21/02;C12Q1/02;(IPC1-7):A61K48/00;C12N5/08 |
主分类号 |
C12N15/09 |
代理机构 |
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