COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF OVARIAN AND ENDOMETRIAL CANCER

摘要

Compositions and methods for the therapy and diagnosis of cancer, such as ovarian or endometrial cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses such an antigen, or a T cell that is specific for cells expressing such an antigen. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian and endometrial cancer. Diagnostic methods based on detecting an ovarian carcinoma protein, or mRNA encoding such an antigen, in a sample are also provided.