| 摘要 |
<p>A compound of formula (I) wherein A is a connecting chain of (C1-3) alkyl; B is O or S; R1 is H, (C¿1-6?) alkyl, halo, CF3, or OR?1a¿ wherein R1a is H or (C¿1-6?)alkyl; R?2¿ is H or Me; R3 is H or Me; R4 is H, (C¿1-4?) alkyl, (C3-4) cycloalkyl and (C1-4)alkyl(C3-7)cycloalkyl; W is selected form formula (i), (ii) or (iii) wherein, a) one of Y is SO2 and the other Y is NR?5¿, provided that both are not the same, wherein R5 is H, (C¿1-6?)alkyl,(C3-6) cycloalkyl, the alkyl being substituted, COR?5o, COOR5p¿ or CONR5pR5q; and each R8 is H, (C¿1-4?) alkyl, (C3-6) cycloalkyl, or (C1-4) alkyl-(C3-6) cycloalkyl; or b) E is CR?8aR8b¿ wherein R?8a and R8b¿ is H, or alkyl and J is CH¿2?; or J is CR?8aR8b¿ and E is CH¿2?, and the dotted line represents a single bond; or c) E is C(O) and J is CR?8aR8b¿ or J is C(O) and E is CR8aR8b and the dotted line represents a single bond; or d) E and J are CR8aR8b and the dotted line represents a double bond. Compounds of formula I have activity against HIV WT and double mutant strains.</p> |
