The invention provides methods of screening commensal and pathogenic bacteri a for previously unidentified vaccine antigens, based upon identifying polypeptide antigens that bind to sera raised against commensal bacterial proteins. Also provided are vaccine compositions and methods of preparing vaccine compositions comprising the antigens identified by the screening methods. Antigens and uses thereof are also described.
申请公布号
CA2441551(A1)
申请公布日期
2002.10.03
申请号
CA20022441551
申请日期
2002.03.22
申请人
MICROBIOLOGICAL RESEARCH AUTHORITY;IMPERIAL COLLEGE INNOVATIONS LIMITED
发明人
HUDSON, MICHAEL JOHN;GORRINGE, ANDREW RICHARD;LANGFORD, PAUL RICHARD;ROBINSON, ANDREW;WEST, DAVID MCKAY;OLIVER, KERRY JANE;BRACEGIRDLE, PHILIPPA;KROLL, JOHN SIMON