发明名称 |
Phenyl substituted alkyl carboxylic acid guanidines with perfluoroalkyl groups, process for their preparation, their use as medicament or diagnostic agent as well as medicament containing the same |
摘要 |
<p>Perfluoroalkyl-substd. phenylalkanoic acid guanidides of formula (I) and their salts are new: Ra, Rb = H, halogen, CN, OR6, 1-8C alkyl, 3-8C cycloalkyl, Or(CH2)aCbF2b+1 or NR7R8; r = 0 or 1; a = 0-4; b = 1-8; R6-R8 = H, 1-8C alkyl, 3-8C alkenyl, 3-8C cycloalkyl, or phenyl or benzyl opt. substd. by 1-3 of F, Cl, CF3, Me, OMe and NR9R10; R9, R10 = H, 1-4C alkyl or 1-4C perfluoroalkyl; x = 1-3; R1-R5 = H, 1-8C alkyl, 3-8C cycloalkyl, Or(CH2)aCbH2b+1, halogen or CN; provided that≥1 of R1-R5, Ra and Rb = Or(CH2)aCbH2b+1.</p> |
申请公布号 |
EP0666252(B1) |
申请公布日期 |
2002.10.02 |
申请号 |
EP19950100675 |
申请日期 |
1995.01.19 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
SCHWARK, JAN-ROBERT, DR.;KLEEMANN, HEINZ-WERNER, DR.;LANG, HANS-JOCHEN, DR.;WEICHERT, ANDREAS, DR.;SCHOLZ, WOLFGANG, DR.;ALBUS, UDO, DR. |
分类号 |
A61K31/165;A01N1/02;A61B10/00;A61P9/06;A61P9/08;A61P9/10;A61P9/12;A61P35/00;A61P43/00;C07C277/00;C07C279/10;C07C279/22;C07D241/26;(IPC1-7):C07C279/22;A61K31/155;G01N33/50 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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