| 摘要 |
1,223,725. L-Threonine by fermentation. AJINOMOTO CO. Inc. 2 July, 1968 [3 July, 1967], No. 31452/68. Heading C2C. L-Threonine is produced by cultivating under aerobic conditions at pH 5-9 on a nutrient medium comprising a source of assimilable carbon, nitrogen, inorganic salts and growthpromoting substance, a threonine-producing strain of a microorganism of the genus Brevibacterium or Corynebacterium which is resistant toα-amino-#-hydroxyvaleric acid. The preferred organisms are B. flavum A.T.C.C. 21269 and C. acetoacidophilum A.T.C.C. 21270, and the medium preferably contains carbohydrates or organic acids as the carbon source (alcohols, hydrocarbons can be used), and ammonia (gaseous or aqueous), ammonium salts or urea as assimilable nitrogen.α-Amino-#-hydroxyvaleric acid is prepared by reacting propionaldehyde with a copper complex of glycine in alkaline medium.
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