发明名称 |
N-SUBSTITUTED BENZYL OR PHENYL AROMATIC SULFAMIDES COMPOUNDS AND THE USE THEREOF |
摘要 |
<p>N-(3,5-bis-disubstituted aminomethyl-4-hydroxy)benzyl aromatic sulfonamides and N-(3,5-bis-disubstituted aminomethyl-4-hydroxy)phenyl aromatic sulfonamides compounds in accordance with the animal test, are active in the prevention and the treatment of cardiac arrhythmia. These compounds are prepared as corresponding diamines by the condensation of optionally substituted aromatic sulfochlorides with p-hydroxybenzylamine, p-aminophenol, or the like, which followed by the Mannich reaction of the resulted corresponding aromatic sulfamides with formaldehyde and secondary amines; or directly obtained by the reaction of the aromatic sulfamides with 4-amino-2,6-bis-disubstituted aminomethylphenol. Subsequently, the diamines are reacted with various acids to provide their salts.</p> |
申请公布号 |
EP1245561(A1) |
申请公布日期 |
2002.10.02 |
申请号 |
EP20000941870 |
申请日期 |
2000.07.03 |
申请人 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES |
发明人 |
BAI, DONGLU;CHEN, WEIZHOU;BU, YUNXIN;WANG, YIPING;DONG, YUELI;KANG, AILI |
分类号 |
A61K31/4453;C07D295/12;A61K31/40;A61K31/4025;A61K31/4545;A61P9/06;C07D295/135;(IPC1-7):C07C311/21;A61K31/535;A61K31/495;A61K31/44;A61K31/18;C07C311/44;C07C311/41;C07C311/29;C07C311/18 |
主分类号 |
A61K31/4453 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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