| 摘要 |
Isolated, enriched, purified or recombinant nucleic acids are provided which encode for a protein having activity as a human telomerase activity modulator characterised in that they comprise a nucleotide sequence encoding for an amino acid sequence selected from those of SEQ ID No 2, SEQ ID No 4, SEQ ID No 5 and SEQ ID No 6 and sequences having at least 70% amino acid homology thereto and an active peptide fragment of any of these sequences. The encoded proteins act as human EST-1 proteins and have use in modulating human telomerase and in screening for modulators of human telomerase. |
