| 发明名称 |
USE OF METHIONINASE AS AN ANTITUMOR AGENT IN ANTI-METHIONINE CHEMOTHERAPY |
| 摘要 |
<p>The present invention describes methods for using methioninase as an antitumor reagent in anti-methionine chemotherapy. Specifically, methioninase is used to slow or stop cell division which can be enhanced with competitive inhibitors of methionine. In addition, methioninase can be used in combination with anti-mitotic agents to increase the therapeutic effectiveness of the anti-mitotic by inducing cell cycle synchronization.</p> |
| 申请公布号 |
EP0668933(B1) |
申请公布日期 |
2002.10.02 |
| 申请号 |
EP19940901634 |
申请日期 |
1993.11.19 |
| 申请人 |
ANTICANCER, INC. |
发明人 |
LISHKO, VALERYI;XU, MINGXU;TAN, YUYING;HAN, QINGHONG;GUO, HUIYAN |
| 分类号 |
C12N15/09;A61K31/00;A61K31/337;A61K31/475;A61K38/00;A61K38/46;A61K38/51;A61K45/00;A61K47/48;A61K48/00;A61P35/00;C12N5/10;C12N9/88;C12P21/00;(IPC1-7):C12Q1/68 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
