PROTECTIVE PEPTIDES DERIVED FROM HUMAN IMMUNODEFICIENCY VIRUS-1 GP160

摘要

A peptide comprising an amino acid sequence of up to 50 amino acids that corresponds to at least a port ion of a protective epitope of HIV and includes an amino acid sequence chosen from the group consisting of:- (a) gly-glu-ile-lys-asn-cys-ser-phe-asn-ile-ser-thr- ser-ile-arg-gly-lys-val-gln-lys-glu-tyr-ala; (b) asn-gly-asn-ala-glu-glu-val-val-ile-arg-ser-ala- asn-phe-thr-asp-asn -ala-lys-thr-ile-ile-val; (c) cys-asn-ile-ser-arg-ala-Lys-trp-asn-asn-thr-leu- lys-gln-ile-asp-ser-lys-leu-arg-glu-gln-phe; (d) gly-ser-asp-thr-ile-thr-leu-pro-cys-arg-ile-lys- gln-ile-ile-asn-met-trp-gln-glu-val-gly-lys ; and (e) val-gln-gln-gln-asn-asn-leu-leu-arg-ala-thr-glu- ala-gln-his-leu-leu-gln-leu-thr-val-thp-gly-ile-lys- gln-leu-gln. The disclosed peptides are immunologically cross-reactive with human immunodeficiency virus 41,000 dalton glycoprotein gp41. These novel peptides are useful in methods of interfering with the effects of HIV-1 upon host cells having cell surface polypeptides capable of binding HIV-1.