alpha,alpha-dibromo-alpha-chloro-acetophenones as synthons

摘要

This disclosure relates to the use of alpha,alpha-dibromo-alpha-chloroacetophenone compounds as intermediates for the preparation of aromatic carbonyl compounds, especially aromatic amides. The compound 2,5-bis(2,2,2-trifluoroethoxy)-alpha,alpha-dibromo-alpha-chloroacetophenone is especially useful as an intermediate for the preparation of flecainide, a known pharmaceutical.