发明名称 NAALADase inhibitors useful as pharmaceutical compounds and compositions
摘要 The present invention relates to N-Acetylated alpha-Linked Acidic Dipeptidase (NAALADase) inhibitors enzyme activity, pharmaceutical compositions comprising such inhibitors, and methods of their use to inhibit NAALADase enzyme activity, thereby effecting neuronal activities, inhibiting angiogenesis, and treating glutamate abnormalities, compulsive disorders, prostate diseases, pain and diabetic neuropathy.
申请公布号 US6458775(B1) 申请公布日期 2002.10.01
申请号 US19990346711 申请日期 1999.07.02
申请人 GUILFORD PHARMACEUTICAL INC. 发明人 JACKSON PAUL F.;MACLIN KEITH M.;WANG ERIC;SLUSHER BARBARA S.;LAPIDUS RENA S.;MAJER PAVEL
分类号 C07D213/55;A61K31/19;A61K31/192;A61K31/194;A61K31/4406;A61K31/4409;A61K31/4418;A61P9/00;A61P13/08;A61P25/00;A61P25/04;A61P25/16;A61P25/18;A61P25/28;A61P25/30;A61P35/00;A61P43/00;C07C309/17;C07C309/24;C07C317/44;C07C323/12;C07C323/52;C07C323/56;C07C327/06;C07C327/12;C07C327/18;C07C327/22;C07C327/36;C07C329/12;C07C333/04;C07C333/14;C07C333/20;(IPC1-7):A61K31/66;A61K31/435 主分类号 C07D213/55
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