Method for synthesizing complexes of platinum with iminoethers and their use as antitumoral drugs and nucleotide-base modifiers

摘要

A process for synthesizing complexes of platinum(II) with iminoethers having the formula: [PtIIX2(L)(L')], where X is a monoanionic ligand, L is an iminoether ligand and L' is an amine group or, exclusively for the case of cyclic iminoethers, a second iminoether ligand. The platinum(II) complexes according to the present invention are suitable for the production of medical remedies having a broad antitumoral spectrum. The complexes of platinum(II) with iminoethers according to the invention are furthermore suitable as agents for modifying nucleotide bases into antisense and/or antigene oligonucleotides.