COMPOSICOES CRISTALIZAVEIS QUE CONTEM UM COMPLEXO ENTRE O DOMINIO DE PROTEASE NS3 DO VIRUS DA HEPATITE C E NS4A CRISTAIS RESULTANTES

摘要

The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.