| 摘要 |
Described are 2-aminopyridine derivatives of formula (I) wherein ring A is a fused 5-7 membered saturated or unsaturated ring wherein from zero to two of the ring members are heteroatoms selected, independently, from nitrogen, oxygen and sulphur, with the proviso that no two adjacent ring members can both be heteroatoms; X is oxygen or a bond; n is an integer from two to six; and R1 and R2 are selected, independently, from (C1-C6) alkyl, aryl, tetrahydronaphthalene and aralkyl, wherein said aryl and the aryl moiety of said aralkyl is phenyl or naphthyl and the alkyl moiety is straight or branched and contains from 1 to 6 carbon atoms, and wherein said (C1-C6) alkyl, said aryl, said tetrahydronaphthalene and the aryl moiety of said aralkyl may optionally be substituted with from one to three substituents, preferably from zero to two substituents, that are selected, independently, from halo (eg, chloro, fluoro, bromo, iodo), nitro, hydroxy, cyano, amino, (C1-C4) alkoxy, and (C1-C4) alkylamino; or R1 and R2 form, together with the nitrogen to which they are attached, a piperazine, azetidine, piperidine or pyrrolidine ring or an azabicyclic ring containing from 6 to 14 ring members, from 1 to 3 of which are nitrogen and the rest of which are carbon. These derivatives exhibit activity as nitric oxide synthase (NOS) inhibitors and also described are pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system and other disorders.
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