| 摘要 |
organic chemistry, pharmacy. SUBSTANCE: invention relates to diarylmethylidenefuran derivatives of the formula (I) where rings A and B mean independently: phenyl, naphthyl, derivative of heterocycle with 5-6 links and with 1-4 heteroatoms, derivative of saturated hydrocarbon ring with 3-7 carbon atoms, at least one of substitutes X1,X2,Y1 or Y2 means obligatory: the group -S(O)nR where n is a whole number 0, 1 or 2; R means a lower alkyl with 1-6 carbon atoms, group -SO2NH2 and it is in para-position; remains mean independently hydrogen atom, halogen atom, lower alkyl with 1-6 carbon atoms, trifluoromethyl group, lower O-alkyl with 1-6 carbon atoms; or X1 and X2 or Y1 and Y2 mean methylenedioxy-group; R1,R2,R3 and R4 mean independently hydrogen atom, halogen atom, lower alkyl with 1-6 carbon atoms, lower halogenalkyl with 1-6 carbon atoms, aromatic radical taken among the group including phenyl, naphthyl, thienyl, furyl or pyridyl; or R1,R2 or R3,R4 mean oxygen atom. These compounds show anti-inflammatory and analgetic properties. The invention relates to also a method of synthesis and a pharmaceutical composition based on thereof. EFFECT: new compounds used in medicine, improved method of synthesis, valuable medicinal properties. 11 cl, 2 tbl, 192 ex |
