发明名称 |
Trypsin substrate, a diagnostic device, and use in assay for urinary trypsin inhibitor |
摘要 |
<p>Compounds of formula (I) are described wherein R1 is a protecting group for Ná, R2 is a protecting group for NG; and R3 is aryl, and wherein the compound of formula (I) is a trypsin substrate such that trypsin cleaves the O-C single bond, which liberates R3-OH. These compounds are used to produce visible colours in dry-phase analytical elements so as to detect quantities of urinary trypsin inhibitor (UTI) in a biological sample such as urine. The compounds of formula (I) provide aromatic esters of Ná (á amino group) and NG (guanidine group) bis-protected arginine that are trypsin substrates. The trypsin hydrolyses esters of arginine and protecting groups on the guanidine moiety.</p> |
申请公布号 |
NZ509863(A) |
申请公布日期 |
2002.09.27 |
申请号 |
NZ20010509863 |
申请日期 |
2001.02.12 |
申请人 |
BAYER CORPORATION |
发明人 |
COREY, PAUL F;FELMAN, STEVEN W;REHM, GARY E;PUGIA, MICHAEL J |
分类号 |
G01N33/493;C07C279/36;C07D207/36;C07D209/36;C07D277/20;C07D277/34;C07D311/16;C12M1/34;C12Q1/37;G01N33/53;(IPC1-7):C12Q1/37;C07D207/337;C07D209/08;C07C279/14;C07D277/30 |
主分类号 |
G01N33/493 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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