| 摘要 |
Described are compounds of formula (I), wherein: X represents: a monocyclic or bicyclic, saturated, partially unsaturated or aromatic heterocycle, having from 5 to 12 ring members, containing from 1 to 3 hetero atoms selected from oxygen, nitrogen and sulphur but containing at least one nitrogen atom, said heterocycle being bonded to the remainder of the molecule by said nitrogen atom, and said heterocycle being optionally substituted, or: a group of formula -NR2R3 wherein R2 represents a hydrogen atom or a linear or branched (C1-C6)alkyl group, and R3 represents an aryl group optionally substituted, a 1,3-dihydro-2H-benzimidazolyl-2-one group, or a linear or branched (C1-C6)alkyl substituted by a monocyclic or bicyclic, saturated, partially unsaturated or aromatic heterocycle, having from 5 to 12 ring members, containing from 1 to 3 hetero atoms selected from oxygen, nitrogen and sulphur but containing at least one nitrogen atom, said heterocycle being optionally substituted, n represents zero or 1, R1 represents a hydrogen atom or a linear or branched (C1-C6)alkyl group, Ra represents a single bond or linear or branched (C1-C6)alkylene chain, A represents a nitrogen atom of a CH group, but A represents only a ch group when Ra represents a single bond, and A represents only a nitrogen atom when n represents zero, E represents a nitrogen atom or a CRe group wherein Re represents either a hydrogen atom, or a bond to a carbon atom of W, It being understood that at least one of the group A and E represents a nitrogen atom, Rb represents a single bond or linear or branched (C1-C6)alkylene chain, one of the carbon atoms of which is optionally replaced by an oxygen atom or a sulphur atom, W represents an aryl or heteroaryl group, each of those groups being optionally substituted, their optical isomers, their hydrates, their solvates and addition salts thereof with a pharmaceutically acceptable acid, it being understood that: "aryl group" is understood to mean a group selected from phenyl, biphenyl, bicyclo[4.2.0]octa-1,3,5-trienyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, indanyl and indenyl "heteroaryl group" is understood to mean an aryl group as defined above containing from 1 to 3 identical or different hetero atoms selected from oxygen, nitrogen and sulphur, "optionally substituted", when associated with "heterocycle", "aryl group" or "heteroaryl group", is understood to mean optionally substituted by one or more identical or different groups selected from halogen, linear or branched (C1-C6)alkyl, hydroxy, linear or branched (C1-C6)alkoxy, mercapto, linear or branched (C1-C6)alkylthio, linear or branched (C1-C6)trihaloalkyl, cyano, nitro, amino, linear or branched (C1-C6)alkylamino, dialkylamino in which each alkyl moiety has from 1 to 6 carbon atoms and is linear or branched, and methylenedioxy,
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