| 摘要 |
The steroids of the formula shown are useful for selectively supplementing estrogen deficiency in the central nervous system without affecting other organs or systems. The variables are defined as follows: R1 is H, -OH, or alkoxy; R2 is H, alkyl, acyl, or -SO2NR10R11 (where R10 and R11 are independently H or alkyl, or together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino or morpholino ring); R3 is H or -OH; R4 is H, -OH, or alkyl; R5 and R6 are independently H or halogen; R7 is H or methyl; R8 is H, -OH, =O, or a group of formula -CR12R13 (in which R12 and R13 are independently H or halogen); R9 is methyl or ethyl; Z is a C,C double bond or an optionally substituted cyclopropane ring; The >CR5R6 is either in the a or b position, R7 being in the b position if >CR5R6 is in the a position, and vice versa.
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