OLIGONUCLEOTIDES FOR REGULATING THE GENE CODING FOR TNF DOLLAR G(A) AND/OR GENES CONTROLLED THEREBY AND USE THEREOF

摘要

The invention relates to oligonucleotides which can directly or indirectly modulate expression of the gene coding for the necrosis factor of alpha tumors (TNF alpha ) in different species or genes controlled thereby. Said oligonucleotides are characterized in that they comprise a constant part - GGGGNGGG -, wherein N = T,A or U, oriented from 5' to 3' or from 3' to 5', which is complementary to a target sequence; and two variable parts, situated on each side of the constant part, enabling the oligonucleotides to interact in a specific manner either directly or indirectly with the target in the gene TNF alpha of the species considered, whereby the base at each of the ends which is adjacent to the constant part is a purine. The invention can be used in diagnosis and therapy and as search tools.