CHITOSAN ODER DERIVAT DAVON ENTHALTENDE ZUSAMMENSETZUNG ZUR ARZNEIMITTELFREISETZUNG MIT DEFINIERTEM Z-POTENTIAL

摘要

PCT No. PCT/GB95/01980 Sec. 371 Date Apr. 21, 1997 Sec. 102(e) Date Apr. 21, 1997 PCT Filed Aug. 21, 1995 PCT Pub. No. WO96/05810 PCT Pub. Date Feb. 29, 1996A drug delivery composition for administration to mucosa is provided. The composition includes a pharmacologically active compound and particles, preferably powder or microspheres, of chitosan or a chitosan derivative or salt wherein the particles are either solidified or partially cross-linked such that they have a zeta potential of +0.5 to +50 mV. Solidified particles are made by treating particles made from a water soluble chitosan salt with an alkaline agent such as sodium hydroxide in a non-acid containing water to render them insoluble.