PIPERAZINE DERIVATIVES, THEIR PREPARATION AND USES IN THERAPY

摘要

Compounds of formula (I) or a pharmaceutically acceptable salt thereof are disclosed: in which R is a group of formula (i), wherein P<2> is phenyl, napththyl heteroaryl or a 5 to 7 membered heterocyclic ring; P<3> is phenyl, naphthyl or heteroaryl; R<1> is NR<4>COR<5>, NR<4>SO2R<5>, CH2NR<4>SO2R<5>, CH2NR<4>COR<5> or CH2NR<4>CO2R<5> where R<4> and R<5> are independently hydrogen or C1-6alkyl; R<2> and R<3> are independently halogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkoxy, COC1-6alkyl, haloC1-6alkyl, cyano or NR<6>R<7> where R<6> and R<7> are independently hydrogen or C1-6alkyl; b and c are independently 0, 1, 2 or 3; Y is a single bond, CH2 or NH; W is -(CR<9>R<10>)t- where t is 2, 3 or 4 and R<9> and R<10> are independently hydrogen or C1-6alkyl or W is a group CH=CH; R is hydrogen, halogen, C1-6alkyl, haloC1-6alkyl, COC1-6alkyl, cyano or C1-6alkoxy; and R is hydrogen or C1-6alkyl. Processes for preparation of the compounds and their uses in therapy, particularly depression, are also disclosed.