发明名称 |
APOLIPOPROTEIN CONJUGATES |
摘要 |
The invention relates to an apolipoprotein construct, an apolipoprotein construct for use as a medicament, a nucleic acid sequence encoding the apolipoprotein construct, a vector comprising the nucleic acid sequence, a method for producing the apolipoprotein construct, and use of the apolipoprotein construct for the preparation of apharmaceutical composition. The presented data document that the constructs according to the invention are capable of binding lipids, are capable of binding cubilin, which is a strong Apo Al receptor, stronger than native Apo A-I and that the plasma half life of the constructs is at least tripled compared to native Apo A-I. Together these data document that the constructs according to the invention are strong candidates for treatment of cardiovascular diseases. |
申请公布号 |
WO0238609(A3) |
申请公布日期 |
2002.09.26 |
申请号 |
WO2001DK00739 |
申请日期 |
2001.11.09 |
申请人 |
PROTEOPHARMA APS;GRAVERSEN, JONAS;MOESTRUP, SOEREN |
发明人 |
GRAVERSEN, JONAS;MOESTRUP, SOEREN |
分类号 |
C12N15/09;A61K38/00;A61K38/47;A61K47/14;A61K47/24;A61K47/28;A61K47/48;A61K48/00;A61P7/00;A61P9/10;C07K14/775;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/62;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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