| 摘要 |
The invention relates to p-thienylbenzyl-amides of formula (I), in which R(1), R(2), R(3), R(4), R(5), R(6) and X have the meanings as cited in the description. The compounds of formula (I) constitute potent agonists of angiotensin-(1-7)-receptors. Due to the stimulation of these receptors caused by the compounds of formula (I), and to the production and release, on endothelial cells, of the vaso-relaxing and cardioprotective messengers cyclic guanosine monophosphate (cGMP) and nitrogen monoxide (NO), said production and release being associated with the stimulation of said receptors, the compounds of formula (I) are suitable for use as valuable medicament active substances for treating and preventing hypertension, cardiac hypertrophy, cardiac power failure, coronary heart diseases such as angina pectoris and endothelial dysfunction or endothelial damages, e.g. as a consequence of arteriosclerotic processes or in the case of diabetes mellitus.
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