P-GLYCOPROTEINS AND USES THEREOF

摘要

The invention pertains to rhesus monkey P-glycoproteins and related P-gylcoproteins which include rhesus-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the rhesus monkey P-gylcoprotein. The invention further relates to methods of using such rhesus monkey P-glycoprotein nucleic acids and polypeptides, especially in methods for determining bioavailability of drugs and for screening for inhibitors of rhesus PGP. Also included are rhesus PGP inhibitors which inhibit rhesus PGP activity by inhibiting the expression or function of rhesus PGP.