TRANSGENIC CELL AND ANIMAL MODELING IGE-MEDIATED HUMAN ALLERGIC RESPONSES AND USE THEREOF

摘要

The invention relates to a transgenic non-human animal cell characterized in that it expresses at least one nucleotide sequence coding for at least one of the chains of human receptors of the fragment Fc&epsis of IgE immunoglobulins (Fc&epsis epsilon R)) and a nucleotide sequence coding fo a human origin, characterized in that the murine gene coding for the chain Fc epsilon )R) of the human receptor is inactive. The invention also relates to a corresponding transgenic animal and a method for understanding physiopathological elements involved in immediate hypersensitivity and/or inflammatory mechanisms. The invention further relates to a method for screening active compounds on interactions between human IgE's and the receptors thereof.