| 发明名称 |
A NOVEL TRP2 ISOFORM CONTAINING HLA-A2 RESTRICTED CYTOTOXIC T LYMPHOCYTE EPITOPES |
| 摘要 |
The present invention relates to a new and potent tumor antigen capable of causing T cells to elicit an immune response and methods of its use in the detection, prevention, and treatment of cancer, preferably melanoma, in mammals. More specifically, this invention relates to the identification of a novel tyrosinase-related protein 2 (TRP2), specifically TRP2-6b protein, and peptides derived from said protein. The present invention therefore also relates to nucleic acid sequences that encode the TRP2-6b protein or peptide fragments thereof. |
| 申请公布号 |
WO02074788(A2) |
申请公布日期 |
2002.09.26 |
| 申请号 |
WO2002US07698 |
申请日期 |
2002.03.15 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ASREPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;KHONG, HUNG;ROSENBERG, STEVEN, A. |
发明人 |
KHONG, HUNG;ROSENBERG, STEVEN, A. |
| 分类号 |
A61K38/00;A61K38/17;A61K39/00;C07H21/04;C07K14/705;C12N9/64 |
主分类号 |
A61K38/00 |
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