发明名称 |
METHOD FOR CREATING POLYNUCLEOTIDE AND POLYPEPTIDE SEQUENCES |
摘要 |
The invention provides methods for evolving a polynucleotide toward acquisition of a desired property. Such methods entail incubating a population of parental polynucleotide variants under conditions to generate annealed polynucleotides comprising heteroduplexes. The heteroduplexes are then exposed to a cellular DNA repair system to convert the heteroduplexes to parental polynucleotide variants or recombined polynucleotide variants. The resulting polynucleotides are then screened or selected for the desired property.
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申请公布号 |
US2002137661(A1) |
申请公布日期 |
2002.09.26 |
申请号 |
US19980205448 |
申请日期 |
1998.12.04 |
申请人 |
ARNOLD FRANCES;SHAO ZHIXIN;VOLKO ALEXANDER |
发明人 |
ARNOLD FRANCES;SHAO ZHIXIN;VOLKO ALEXANDER |
分类号 |
C12N15/09;C07K14/435;C12N15/10;C12P19/34;C12Q1/68;(IPC1-7):A61K31/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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