发明名称 |
COMPOSITIONS AND METHODS FOR DELIVERY OF A MOLECULE INTO A CELL |
摘要 |
Provided is a composition comprising a Vpr polypeptide conjugated to a therapeutic molecule. Preferably, the Vpr comprises synthetic Vpr. The therapeutic molecule can comprise any molecule capable of being conjugated to Vpr or a fragment thereof, including a polypeptide, a polynucleotide, and/or a toxin. The invention additionally provides a method for delivering a molecule into a cell. The method comprises contacting the cell with a conjugate comprising a Vpr polypeptide conjugated to the molecule. The invention further provides a method for modulating the expression of a transgene in a cell, a method for killing a target cell population in a subject, a method for increasing the sensitivity of cells to radiation therapy, and a method for inhibiting cell proliferation.
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申请公布号 |
WO0190159(B1) |
申请公布日期 |
2002.09.26 |
申请号 |
WO2001US16943 |
申请日期 |
2001.05.23 |
申请人 |
THE J. DAVID GLADSTONE INSTITUTES;SCHUBERT, ULRICH;HENKLEIN, PETER |
发明人 |
SHERMAN, MICHAEL, P.;GREENE, WARNER, C.;DE NORONHA, CARLOS, M., C.;SCHUBERT, ULRICH;HENKLEIN, PETER |
分类号 |
C12N15/09;A61K31/7088;A61K38/00;A61K38/16;A61K41/00;A61K45/00;A61K47/48;A61K48/00;A61P31/00;A61P31/04;A61P31/12;A61P33/00;A61P35/00;A61P43/00;C07K14/16;C12N5/06;C12N5/10;C12N15/87;(IPC1-7):C07K14/16 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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