LEPTIN INDUCED GENES

摘要

LIG 46, a gene whose expression is induced by leptin is disclosed. LIG46 represents a target for the development of therapeutic agents for use in modulating body weight. For example, agents that alter the expression or activity of LIG46 can be used to modulate body weight. Such agents can be identified using cellular, in vitro, or in vivo assays which monitor the expression or activity of LIG46. LIG46 nucleic acid molecules and polypeptides are potentially useful therapeutically and diagnostically.