| 摘要 |
Disclosed is a method of detecting amyloid-containing deposits in a mammal without administering exogenous chemicals such as fluorophores or chromophores. The method includes subjecting tissue of a mammal, preferably tissue of a mammal suspected of having at least one form of amyloidosis to autofluorescence-initiation, preferably by subjecting the tissue to at least excitation incident radiation from a light source having a wavelength of lig ht within the range of from about 360 to about 370 nm, and more preferably to illumination incident radiation from a light source having wavelengths in th e visible spectrum, to produce an emitted light signal beam and a reflected light signal beam. The method also preferably includes detecting the presenc e of emitted light having a wavelength of from about 400 nm to about 460 nm. T he method can be used to diagnose amyloidosis in living mammals using relativel y non-invasive imaging apparatus, and it can be used to monitor the efficacy o f treatment, or screen effective treatments for amyloidosis.
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