| 发明名称 |
N- heterocyclic inhibitors of TNF-alpha expression |
| 摘要 |
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-alpha expression utilizing compounds of the present invention are also disclosed.
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| 申请公布号 |
US2002137747(A1) |
申请公布日期 |
2002.09.26 |
| 申请号 |
US20010891750 |
申请日期 |
2001.06.26 |
| 申请人 |
MORIARTY KEVIN JOSEPH;SHIMSHOCK YVONNE;AHMED GULZAR;WU JUNJUN;WEN JAMES;LI WEI;ERICKSON SHAWN DAVID;LETOURNEAU JEFFREY JOHN;MCDONALD EDWARD;LEFTHERIS KATERINA;WROBLESKI STEPHEN T.;HUSSAIN ZAHID;HENDERSON IAN;METZGER AXEL;BALDWIN JOHN J.;DYCKMAN ALARIC J. |
发明人 |
MORIARTY KEVIN JOSEPH;SHIMSHOCK YVONNE;AHMED GULZAR;WU JUNJUN;WEN JAMES;LI WEI;ERICKSON SHAWN DAVID;LETOURNEAU JEFFREY JOHN;MCDONALD EDWARD;LEFTHERIS KATERINA;WROBLESKI STEPHEN T.;HUSSAIN ZAHID;HENDERSON IAN;METZGER AXEL;BALDWIN JOHN J.;DYCKMAN ALARIC J. |
| 分类号 |
A61K31/40;A61K31/551;C07D251/52;C07D251/54;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D403/14;C07D405/14;C07D521/00;(IPC1-7):A61K31/53;A61K31/503;A61K31/44;C07D239/02 |
主分类号 |
A61K31/40 |
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