| 发明名称 |
METHOD FOR CLEAVING HUMAN GROWTH HORMONE GH |
| 摘要 |
The invention relates to a method for cleaving human growth hormone GH, by means of matrix metalloproteinase MMP. It has been found that MMP-3 cleaves the hormone into two fragments, of which the 16kDa fragment is stable. The invention provides means which positively influence tumour growth, proliferative diabetic retinopathy and also angiogenesis, in particular on treatment of coronary infarct, retarded wound healing, menstrual cycle disturbances and others, by means of regulation of the human growth hormone.
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| 申请公布号 |
WO02074945(A1) |
申请公布日期 |
2002.09.26 |
| 申请号 |
WO2002EP02606 |
申请日期 |
2002.03.09 |
| 申请人 |
IBFB GMBH PRIVATES INSTITUT FUER BIOMEDIZINISCHE FORSCHUNG UND BERATUNG;HERMANN, KONRAD;ARKONA, CHRISTOPH |
发明人 |
HERMANN, KONRAD;ARKONA, CHRISTOPH |
| 分类号 |
A61K31/517;A61K31/549;A61K38/00;A61K38/48;A61P9/00;A61P9/10;A61P15/00;A61P17/00;A61P17/02;A61P35/00;C07K14/61;C12N9/64;C12N15/57;(IPC1-7):C12N9/64 |
主分类号 |
A61K31/517 |
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