PROCESS FOR PREPARING N6-SUBSTITUTED AMINOPURINE RIBOFURANOSE NUCLEOSIDES

摘要

An improved process for preparing N6-substituted aminopurine ribofuranose nucleosides. Compounds of this type are known to be useful in the preparation of compounds having activity at adenosine receptors, e.g. Adenosine A1 receptor. The process comprises the step of reacting a 6-halopurine ribofuranose nucleoside with an amine in the presence of CaCO3, wherein acid is added to the reaction mixture.