摘要 |
The present invention patent refers to the isolation and purification of peptides secreted by serpent venom glands, specifically Bothrops jararaca; to the peptide thus obtained, as well as to the production procedures by genetic engineering techniques in procaryotic and eukaryotic systems; to the engineered peptide thus obtained; to the production of said peptide by chemical synthesis, as well as to the peptide resulting from this chemical processing. It also refers to the utilization of said peptides, obtained by different procedures, in distinct pharmaceutical compositions, and introduced into the organism by a variety of means, in order for them to act as inhibitors of vasopeptidases, and consequently reduce systemic arterial blood pressure, and show local vasodilating action. |
申请人 |
BIOLAB SANUS FARMACEUTICA LTDA.;FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO;MARTINS DE CAMARGO, ANTONIO, CARLOS;CALHETA VIEIRA PORTARO, FERNANDA;FERRAGINI MURBACK, ALESSANDRA;ALVES IANZER, DANIELLE;POLISELLI FARSKY, SANDRA, HELENA;PALMA, MARIO, SERGIO |
发明人 |
MARTINS DE CAMARGO, ANTONIO, CARLOS;CALHETA VIEIRA PORTARO, FERNANDA;FERRAGINI MURBACK, ALESSANDRA;ALVES IANZER, DANIELLE;POLISELLI FARSKY, SANDRA, HELENA;PALMA, MARIO, SERGIO |