| 摘要 |
<p>The methods of the present invention for diagnosing pathogen infections are based on determining a library of mass spectral patterns of expression of immune system modulators (cytokines and chemokines) in biological samples taken from animals known to be infected with known pathogens at various times after exposure and infection. The patterns in the library are compared to mass spectral patterns of expression of immune system modulators in the same type of biological samples taken from animals that may have been exposed and infected by a pathogen in the library. A diagnosis of pathogen infection is made if there is a match between a pattern from the potentially infected animal and a pattern in the library. Patterns of expression of other molecular markers of infection can also be used in these diagnostic methods, including hydroxyeicosatraenoic acids, prostaglandins, and truncated receptors for immune modulators secreted by infected cells or pathogens.</p> |
