DNA molecules encoding single strand gap response proteins involved in activation of a DNA repair/cell cycle checkpoint pathway

摘要

The present invention relates to isolated DNA molecules encoding mammalian single strand gap response proteins involved in activation of a DNA repair/cell cycle checkpoint pathway. Expression systems and host cells containing those DNA molecules as well as the proteins themselves and antibodies raised against them are also disclosed. The DNA molecules, proteins, and antibodies can be used for diagnostic purposes, while the DNA molecules also have therapeutic utility. In addition, transgenic animals can be produced where the gene encoding a single strand gap response protein is disrupted or deleted. As a result, these animals are characterized by spontaneous tumor development.