USE OF A C1 ESTERASE INHIBITOR FOR PREVENTING OR DELAYING REJECTION OF XENOTRANSPLANTS IN MAMMALS

摘要

PURPOSE: Provided is the use of a preparation comprising a C1 esterase inhibitor (C1-INH) for preventing or delaying hyperacute rejection of xenotransplants (HAR) and acute rejection of xenotransplants (AVR) to improve the prospects of success in xenotransplantation. CONSTITUTION: The use of a preparation comprises a C1 esterase inhibitor (C1-INH) for preventing or delaying hyperacute and/or acute rejection of xenotransplants in mammals. A therapeutically effective amount of the C1-INH preparation is administered to the recipient organism before the transplantation and, after the transplantation has taken place, the organism receives daily doses of the C1-INH preparation in an amount sufficient to prevent rejection of the transplant.