| 摘要 |
<p>The invention is concerned with a process for the manufacture of 3-amino-pyrrolidine derivatives of the formula <CHEM> wherein R<1> signifies hydrogen, alkyl, cyclo-alkyl, alkenyl, aryl or an amino protecting group; and R<2>, R<3> each independently signify hydrogen, alkyl, cyclo-alkyl, alkenyl or aryl; by converting a compound of the formula <CHEM> wherein X signifies a protected hydroxy group; in the presence of a primary amine of the formula R<1>NH2 into the pyrrolidine derivative of the formula <CHEM> wherein X and R<1> have the aforementioned significances; which is subsequently reacted in the presence of R<2>R<3>NH under pressure; and with the use of this process for the production of vinylpyrrolidinone-cephalosporin derivatives.</p> |
