发明名称 |
CATALYTIC DOMAINS OF THE HUMAN HEPATOCYTE GROWTH FACTOR RECEPTOR TYROSINE KINASE, AND MATERIALS AND METHODS FOR IDENTIFICATION OF INHIBITORS THEREOF |
摘要 |
The identification, isolation, purification, and characterization of the catalytic domain of the human hepatocyte growth factor receptor kinase (hHGFR) are described. A crystal structure of the hHGFR kinase domain is reported herein. This structure provides a thr ee- dimensional description of the binding site of the hHGFR for structure-based design of small molecule inhibitors thereof as therapeutic agents. The kinase domain of human HGFR an d its associated crystal structure is described for use in the discovery, identification and characeterization of modulators of human HGFR.
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申请公布号 |
CA2378494(A1) |
申请公布日期 |
2002.09.23 |
申请号 |
CA20022378494 |
申请日期 |
2002.03.25 |
申请人 |
AGOURON PHARMACEUTICALS, INC. |
发明人 |
SARUP, JAY;MROCZKOWSKI, BARBARA;PARGE, HANS;MCTIGUE, MICHELE ANN;ZHU, JEFF;MURRAY, BRION WILLIAM;HICKEY, MICHAEL |
分类号 |
C12N15/09;C07K14/71;C07K14/715;C12N1/21;C12N5/10;C12N9/12;C12N15/12;C12P21/00;C12Q1/02;C12Q1/48;C12R1/91;(IPC1-7):C12N15/12;G06F17/00;C12Q1/00;C07D513/04;C12N15/54;G01N33/566;C12N15/63 |
主分类号 |
C12N15/09 |
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