New modified Cry protein, useful as insecticide, comprises at least one additional pepsin cleavage site to reduce persistence in mammalian gut

摘要

Modified Cry protein (I) that is sensitive to pepsin and comprises at least one additional pepsin cleavage site (PCS), is new. Independent claims are also included for the following: (a) increasing pepsin sensitivity of Cry proteins by incorporating at least one extra PCS; (b) polynucleotides (II) that encode (I); (c) chimeric genes (CG) that contain a promoter, (II) and terminator; (d) expression or transformation vector (III) that contains CG; (e) host organism (IV) transformed with (III), also, where the organism is a plant, its parts and seeds; (f) production of (I) by growing (IV); and (g) mono- or polyclonal antibodies (Ab) directed against (I).