发明名称 |
USE OF MATRIX METALLOPROTEASE INHIBITORS FOR THE TREATMENT OF CANCER |
摘要 |
The invention relates to the use of an active agent, particularly an inhibitor, in treating cancer by influencing, preferably inhibiting the expression of matrix-metalloproteases. The targets for this active agent can especially related to downstream regulators of the matrix-metalloprotease 9 (MMP-9) signal transduction pathway. According to the invention, especially inhibitors of p38beta and p38gamma as also of mitogen-activated kinase kinase 6 (MKK6) and mitogen-activated kinase kinase 3 (MKK3) can be applied.
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申请公布号 |
WO0205792(A9) |
申请公布日期 |
2002.09.19 |
申请号 |
WO2001EP08234 |
申请日期 |
2001.07.17 |
申请人 |
SIMON, CHRISTIAN;ZENNER, HANS-PETER |
发明人 |
SIMON, CHRISTIAN;ZENNER, HANS-PETER |
分类号 |
A61K45/00;A61K31/00;A61K31/4439;A61K38/00;A61K48/00;A61P35/00;A61P43/00;(IPC1-7):A61K31/00;A61K31/443 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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