发明名称 |
A CRYSTAL OF BACTERIAL CORE RNA POLYMERASE WITH RIFAMPICIN AND METHODS OF USE THEREOF |
摘要 |
A detailed three-dimensional structure of rifampicin bound to a core bacterial RNA polymerase (Rif-RNAP) is provided. Crystals of the Rif-RNAP are also included in the invention. The present invention further provides procedures for identifying agents that can inhibit bacterial proliferation through the use of rational drug design predicated on the crystals and crystallographic data disclosed.
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申请公布号 |
WO02073192(A1) |
申请公布日期 |
2002.09.19 |
申请号 |
WO2002US07535 |
申请日期 |
2002.03.11 |
申请人 |
THE ROCKEFELLER UNIVERSITY;DARST, SETH;CAMPBELL, ELISABETH |
发明人 |
DARST, SETH;CAMPBELL, ELISABETH |
分类号 |
C12N9/12;C12Q1/18;C40B30/04;G01N33/68;(IPC1-7):G01N33/48 |
主分类号 |
C12N9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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