Divalproex sodium dosage forms and a process for their production

摘要

The present invention is directed to a new process for granulating valproate compounds, such as divalproex sodium, in which the compound is melted in the absence of a binder and admixed with one or more excipeints to produce granules. The resulting dosage forms have an increased drug loading factor in the range of 75 w/w % to 90 w/w %.