FLOW THROUGH DEVICE FOR TWO DIMENSIONAL INCUBATION AND/OR HYBRIDIZATION ON SOLID SUPPORTS

摘要

The present invention provides flow through devices for incubation and/or hybridisation on two-dimensional solid supports. In a first device the following parts are provided: a. a solid support comprising a target for binding; b. a support holder i) comprising the solid support as one of the walls including an incubation space, ii) two reservoirs on one each side of the incubation space where the first one allows test fluid to be entered into the incubation space, and the second one allowing collection of the test fluid; c. means for providing pressure, allowing transport of the test fluid from one reservoir to the other; d. a control system for moving the fluid from one reservoir along the incubation chamber to the other reservoir and back, allowing repeated exposure of test fluid components to the component present on the solid support. In a second device the following parts are provided: a. a solid support comprising a target for binding, b. a wall of the support holder opposite to the solid support, part of which consisting of one or more roatable disc(s), c. a mechanical system for controlled rotating of the disc(s), d. means for controlling the inflow of test fluid, and rotating the disc(s). The invention also comprises assemblies in which two or more of the above devices are combined.