METHOD OF PREPARING TETRAKIS(2-ALKOXYISOBUTYLISONITRILE)COPPER(I)TETRAFLUOROBORATE DERIVATIVES AND NOVEL COMPOSITION CONTAINING THEM FOR LABELING AGENT OF RADIOACTIVE MATERIALS THEREOF

摘要

PURPOSE: A method of preparing tetrakis(2-alkoxyisobutylisonitrile)copper(I)tetrafluoroborate derivatives stably in high yield and a novel composition containing them for a labeling agent of radioactive materials thereof are provided. CONSTITUTION: The method for preparing tetrakis(2-alkoxyisobutylisonitrile)copper(I)tetrafluoroborate derivatives comprises the steps of: alkoxylating methylhalide(2) by reacting it with mercuric acetate, sodium hydroxide and sodium borohydride, sequentially under an appropriate solvent; azidating the alkoxy compound(3) by reacting it with sodium azide; reducing the azide compound(4) into an amine group in the presence of lithium aluminum hydride; carrying out the isonitrilization of the compound(5) by using inorganic salt in the presence of chloroform and phase transfer catalyst; and reacting the isonitrile compound(6) with a copper compound(7) to obtain tetrakis(2-alkoxyisobutylisonitrile)copper(I)tetrafluoroborate derivative represented by the formula(1): Cu((CH3)2C(OR)CH2NC)4BF4, in which R is C1-C4 lower alkyl or branched alkyl; X is halogen; and R' is C1-C4 lower alkyl.