| 摘要 |
The present invention relates to a chemical compound of the formula (I): in which R1 is: R2 is H, alkyl, which may optionally be substituted by halogen or N2, or NH2; m and o are 0 to 3 and n is 0 or 1; ap, bq and cr are amino acid chains and p, q and r denote the number of amino acids, where a and/or b and/or c may likewise comprise at least one side chain represented by (CH2)mYn(CH2)oC(Z)R2 where Y, Z, R2, m, n, and o have the same meanings as in formula (I), and p, q and r may be identical or different and are an integer from 0 to 1000; R3 and R4 are, independently of one another, H, alkyl, aryl, a heterocycle, an amino protective group or a carboxyl protective group; R5 and R6 are, independently of one another, alkyl which may comprise at least one heteroatom selected from N, O and S, aryl or a heterocycle; X is a methine group, a nitrogen or phosphorus atom; Y is an oxygen atom, sulfur atom or an NH group; and Z is an oxygen atom, sulfur atom or an NR7 group, where R7 is H, alkyl, aryl, a heterocycle, O-alkyl, O-aryl, O-heterocycle, NR2 or NHCONR2, where R is H, alkyl, aryl or a heterocycle, and to the use thereof as inhibitor of transglutaminases.
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