| 摘要 |
beta-peptides that have antibacterial properties. These antibacterial B-peptide can have the following formula: wherein R1 is H, an alkyl group including 1-4 carbon atoms, phenyl, heteroaryl, or an alkyl-aryl; R2 is an amine-containing alkyl group having the formula -(CH2)mNH2, wherein m=1, 2, 3, 4, or 5, (CH2)xNHC=NHNH2 wherein x is 1, 2, 3, 4, or 5, a pyridyl, an alkylpryidyl, an amidine-substituted benzyl, a phenyl group, or a cyclic amidine; R3 is H, an alkyl group including 1-4 carbon atoms, phenyl, heteroaryl, or an alkyl-aryl; X is -NH2, -OH, -NHR, or OR where R is alkyl aryl or acyl groups either free or polymer-supported, a carboxamide, a substituted carboxamide, or a polymer; Y is H, an alkyl group, an acyl group, an acyl-terminated polymer, a sulphonamide, an ether, a urea, a urethane, or a polymer; and n is 2, 3, 4,5, 6, or 7.
|
