发明名称 |
HETEROLOGOUS FUSION PROTEIN CONSTRUCTS COMPRISING A LEISHMANIA ANTIGEN |
摘要 |
The present invention provides a recombinant nucleic acid molecule encoding a fusion polypeptide, wherein the recombinant nucleic acid comprises a heterologous polynucleotide sequence encoding an antigen or an antigenic fragment, and a Leishmania</i> polynucleotide sequence encoding a polypeptide or fragment thereof, wherein the Leishmania</i> polynucleotide is selected from the group consisting of TSA polynucleotide, LeIF polynucleotide, M15 polynucleotide, and 6H polynucleotide. The invention also provides an expression cassette comprising the recombinant nucleic acid molecule, host cells comprising the expression cassette, compositions, fusion polypeptides, and methods of their use in diagnosis or in generating a protective immune response in hosts.
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申请公布号 |
WO02072792(A2) |
申请公布日期 |
2002.09.19 |
申请号 |
WO2002US08223 |
申请日期 |
2002.03.13 |
申请人 |
CORIXA CORPORATION;SKEIKY, YASIR;BRANNON, MARK;GUDERIAN, JEFFREY |
发明人 |
SKEIKY, YASIR;BRANNON, MARK;GUDERIAN, JEFFREY |
分类号 |
A61K39/00;C07K14/35;C07K14/44;C12N1/21;(IPC1-7):C12N/ |
主分类号 |
A61K39/00 |
代理机构 |
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地址 |
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