发明名称 |
DORMANCY - INDUCED MYCOBACTERIUM PROTEINS |
摘要 |
A method for the identification of an anti-mycobacterial agent that modulates the activity and/or expression of a protein expressed by a Mycobacterium in non-oxygen limiting stationary phase, hypoxic stationary phase or hypoxic growth phase, which method comprises: (i) contacting a test agent and a protein selected from RV3133c, Rv2623, Rv2626c, a variant of Rv3133c, Rv2623 or Rv2626 and a fragment of Rv3133c, RV2623, Rv2626c or said variant, or a polynucleotide or expression vector encoding said protein; (ii) monitoring the effect of the test agent on the activity and/or expression of said protein, thereby determining whether the test agent modulates the activity and/or expression of a protein expressed by a Mycobacterium in non-oxygen limiting stationary phase, hypoxic stationary phase or hypoxic growth phase. |
申请公布号 |
WO0248391(A3) |
申请公布日期 |
2002.09.19 |
申请号 |
WO2001EP14551 |
申请日期 |
2001.12.11 |
申请人 |
INSTITUTE OF MOLECULAR AND CELL BIOLOGY;DICK, THOMAS;CALVIN, BOON, KA, KHIU |
发明人 |
DICK, THOMAS;CALVIN, BOON, KA, KHIU |
分类号 |
A61K39/00;C07K14/35;G01N33/569 |
主分类号 |
A61K39/00 |
代理机构 |
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